New York is a popular travel destination. Whether its business or tourist travelers, the state plays host to millions of visitors each year. Being the largest financial district in the world, New York undoubtedly attracts millions of business travelers each year. As such, New York doesn’t only have a wide array of comfortable lodging options; it also has a whole line of car rental companies. With the many options available, how do you pick which New York car rental company to use? 1. Check your discounts. Your credit card, bank, airline, hotel or other businesses you use are likely to have rewards programs, promo packages and other agreements with certain New York car rentals that provide significant discounts. You don’t want to pass this up. 2. Check their discounts. New York car rental companies routinely offer specials to snag more customers. The competition is stiff and you’d have at least ten companies vying for your business. Check their discount offers. You may get as much as 50% off if you take out a vehicle over the weekend. 3. Look for special features. Some rental car companies have fleets that carry GPS. Some offer roadside assistance. They don’t have to provide these value-added services themselves. Other services, such as roadside assistance can be provided by affiliate businesses. 4. Consider office locations. Check company locations. You’d want to rent a car from a company with locations in the areas you are traveling to so that if and when you have to, switching cars happens fast and easy. 5. Know your car. Check your prospect’s fleet. New York car rentals are often classified into various categories for price variations. The trick is to book for a lesser, lower-classed vehicle and book ahead. Especially during peak travel seasons, you are more likely to be upgraded, never downgraded, when there are glitches, switches and confusion. Customer Feedback and Reviews If you are shopping for New York car rentals for the first time, the choice can be a hit-and-miss. But if you do a bit of Google-ing, you could dramatically tip the odds to your favor. There are plenty of online forums and feedback sites that you can dig up to see what customers say about the service they’ve had with your options. Of course, you don’t have to look up feedback for every single rental car company within a two-mile radius from your destination; pick two or three of your best bets based on the above criteria, and then check the feedback for those. If the items on your shortlist do not meet your expectations based on feedback, by all means scratch them from the list and replace them with other items. Just a note on evaluating feedback and service reviews though. If you encounter a car rental company with a half-positive, half-negative general feedback rating, scratch it from the list right away and look for a better-rated, positively reviewed option. Pay close attention to the negative reviews and see what areas the complaints were centered on. Some companies offer you discounts and freebies in exchange for bad service. You don’t want that kind of business.
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What would you do if your dog had a medical emergency? Most dog owners don’t give this much thought until they are forced to deal with the situation themselves. The first thought that comes to most people’s mind is to call 911- that’s smart. After you make that call, the response to your pooches medical emergency is different than you may think. This article discuses what happens after you make that call and different departments that can help in an emergency.
If you have ever been in an emergency situation with your dog you know just how traumatic it can be. There might be blood, broken bones or deep cuts and you are left scrambling to figure out how to transport your best friend to the nearest emergency facility. In some situations rescue is required; however, it is a frustrating situation because 911 does not assist in canine accidents or medical transport. Often you will be responsible for freeing, carrying and driving your dog in your own car to the nearest animal ER. With you driving there is often noting that you can do to help your pet on the way. You will not be able to comfort your dog, administer CPR or apply pressure to any wounds. In response to these needs from pet owners just like you several emergency services specifically for dogs have been created over the last few years.
While most fire departments across the country are facing budget cuts or closing stations altogether, many animal rights activists are raising money to provide canine oxygen masks to stations not equipped with the life saving devices. Most major fire departments are equipped with animal oxygen masks to provide life saving care upon the rescue of a pet from a burning building. Unfortunately, human masks do not fit dogs or cats so they are often vulnerable to complications from smoke inhalation or shock. To make matters worse dogs tend to hide out of fear in the event of a house fire making them more difficult to find thus leaving them exposed to smoke inhalation for longer periods of time. Many local animal activists have rallied to provide fund raising efforts to provide local stations with pet masks while other cities have put these devices in their city budgets.
Fire fighters are also the proper department to call if you need help freeing a tuck or stranded animal. While 911 provides emergency response services to people through police officers, fire fighters are the leaders on the animal front. This means that there is some preparation involved on your part. Rather than depending on the standard emergency catch all number of 911 you will need to research and write down the number of your local fire station(s) in order to ask for help. It is also a good idea to keep this number handy with the names and numbers of local 24 hour animal emergency facilities in the area. As a pet owner you must be prepared to act quickly in an emergency and scrabbling for telephone numbers at the last minute can waste valuable time that could be spent saving your dog’s life.
Other life saving emergency services specifically for dogs include animal ambulance services. These services provide emergency transport to local Veterinary facilities for treatment. These services are very similar to human ambulances in that the vehicles themselves are equipped with life saving first aid equipment and are often staffed with certified animal emergency medical technicians. Animal ambulances can move and restrain injured animals without causing further injury, provide life-saving first aide in route to the ER and have specialized equipment that owners do not have access to.
Animal ambulance services are popping up in cities across the country. For instance, AmbuVet serves New York City. Phoenix’s All Animal Rescue & Transportation is an ambulance agency that also helps wildlife. Animal Ambulances of Southern California has service from Ventura County to San Diego. Animal Rescue League of Boston operates a few animal ambulances, while the MSPCA operates the nation’s premiere equine emergency response service. Washington D.C., Chicago, and many other metropolitan areas have one or several small ambulance companies specializing in pets. If you can not find a company specializing in this service in your area try contacting the largest animal emergency facility in your area to find out if they offer transport services. An internet search will be most helpful in finding services near you
Scientists can create fruit flies that live a 250% longer life span. We are also finding many ways to get old human cells to behave like young ones do. “Unless ye be as little children, you cannot enter the Kingdom of Heaven,” so lets get started on our second childhood, right away. You’ll not only have more fun in your function, you’ll likely enjoy living longer as well…
Attitude: Gratitude. Don’t worry, be happy. A study of 1,500 centenarians found that diets, activity levels, and smoking habits varied widely, but nearly all have a good sense of humor and don’t worry.
Calorie restriction is crucial. The best way to restrict calories is to focus your diet on greens and vegetables and minimize commercial, refined and processed foods, sugars and carbohydrates. Make sure you get an adequate balance of protein, but not an excess. The common American diet contains 4 times the optimal protein. Reduce calories to about two-thirds of what it takes to maintain your normal weight if you are at all overweight. Initial weight loss tapers off as your metabolism adjusts to a lower metabolic rate. Get plenty of antioxidants in your diet to prevent free-radical damage. Occasionally enjoy no sulfite added wines if tolerated and eat lots of berries. See below for specific antioxidant nutrients.
Keep homocysteine low. High levels of homocysteine correlate strongly with most degenerative diseases of aging, especially heart attacks and strokes. You can check your homocysteine level with a blood test if you want. You can lower homocysteine by eating raw fresh organic dark leafy greens and taking methyl donors, the most commonly deficient vitamin group on commercial food diets.
Avoid sugar and minimize grains.
Resveratrol from grapes (Vitis vinifera) or giant knotweed (Polygonum cuspidatum) extends the life of yeast (Saccharomyces cerevisiae) cells by 70% via a niacin-dependent enzyme, Sir2. Humans have a homologous enzyme SIRT1, a deacetylase. Resveratrol works synergistically with Quercetin (water soluble Quercetin is best absorbed). Resveratrol is found in wine, with white wine containing only about 10% of red’s 200 to 5,000 mcg per glass.
Polygonum multiflorum (Fo ti, Ho Shou Wu, Japanese knotweed) and Centella asiatica (gotu kola) are thought to extend longevity. Polygonum multiflorum is said to contain Vitamin X. Pharmacology studies show that an extract improves the cardiovascular system, enhances immune functions, slows degeneration of glands, increases antioxidant activity, and reduces the accumulation of lipid peroxidation.
Chen Keji and Zhang Wenpeng, Advances on antiaging herbal medicines in China , Abstracts of Chinese Medicine 1987; 1(2): 309-330.
Processed Polygonum multiflorum affects the antioxidant enzyme superoxide dismutase (SOD), accumulation of lipid peroxidase, and enhances cellular immunity, while unprocessed herb is much less effective.
Ye Dingjiang, et al., Immunopharmacological studies of ho-shou-wu and its preparations , 1987 Bulletin of Chinese Materia Medica 12(3): 21-24.
Pan Hongping, Wang Hong, and He Tingcai, Processed root tuber of Polygonum multiflorum on SOD and LPO levels in mice , China Journal of Chinese Materia Medica 1993; 18(6): 344.
Among the Chinese herbal prescriptions tested and shown useful for lowering the risk factors associated with aging and death, were (15):
Shou Xing Bu Zhi: with main components ho-shou-wu, dioscorea, rehmannia, codonopsis (or ginseng)
Essence Restoring Decoction: with main components ho-shou-wu, rehmannia, cuscuta, astragalus, achyranthes, and cynomorium.
Rejuvenating Decoction: with main ingredients ho-shou-wu, astragalus, and salvia.
Other antiaging botanicals studied extensively include:
Panax quinquifolia (ginseng)
(dong quai, tang-kuei)
Eleutherococcus senticosus (Siberian ginseng, eleuthero ginseng)
Avoid conventional medicine: Mortality rates are 2 to 5% higher in regions that spend more on conventional medicine, comparing areas with the same level of health. Every time physicians and surgeons go on strike, the death rate drops, until they go back to work. This has been documented in Israel, California, South America and elsewhere.
Gerovital: GH3: Ana Aslan’s clinic in Romania has treated tens of thousands of people by injection. Drug-free GH3 is now available in oral form.
Live Fetal Lamb Cells: over 50,000 patients have been treated at Clinic La Prairie in Switzerland with fresh fetal lamb cell injections.
M-state minerals: Human blood typically lives only about 10 minutes out of the body, but in rare cases stays alive for hours or even days. One alchemist and his partner found their blood stayed alive for three days after years of ingesting m-state minerals. This effect is only found in one out of thousands of samples, usually in those with strong spirituality.
Vitamin C: supplementation of at least 750 to 1,000 mg twice a day is recommended. Consider fat soluble vitamin C (Ascorbyl Palmitate) which is a form of the antioxidant that gets into the cell membranes that are highly sensitive to oxidation, and Ester C, which gets into the cytoplasm twice as well as ascorbic acid and stays in the cells twice as long.
CoQ10: protects against heart disease. Having a high CoQ10 level and a low homocysteine level keeps you out of the Emergency Room. Consider taking 100 mg of CoQ10 daily if you are in Phase 1 or have a high heart risk. Blood levels can be monitored if necessary.
L-Carnosine: Physiological concentrations (20-30 micromoles) in standard media prolong the in-vitro life span of human fibroblast cells and strongly reduce the normal features of senescence (aging). In laboratory studies, carnosine clearly improves external appearance of animals and produces beneficial effects on behavior and average life span. Benefits include:
most effective natural glycation fighter
protects proteins from AGE toxicity
extends lifespan 20 % in senescence-accelerated mice
dramatically improves behavior and appearance of old mice
rejuvenates senescent human cells in culture
increases cell life span
restores youthful appearance and growth patterns to cells approaching senescence
Alpha Lipoic Acid & Acetyl L-Carnitine:
Age-Related Mitochondrial Decay Increases Oxidative Stress in the Aging Rat Heart: Improvement by Acetylcarnitine and/or (R)-A-Lipoic Acid
T.M. Hagen and R. Moreau
Department of Biochemistry and Biophysics and the Linus Pauling Institute, Oregon State University
Mitochondria are critical to cell function. They are the site of energy production for the cell and play a critical role in cellular calcium balance. They also serve as a “gatekeeper” for apoptosis (self-induced cell death). Mitochondria are both the source and the target of reactive oxygen species, which induce oxidative damage leading to energy deficits, metabolic upset, and ultimately cell death.
We compared mitochondrial function in isolated heart, liver and brain cells of young and old rats. Energy production and electron transport efficiency was decreased in the cells from the old animals. Cardiolipin, a substance needed for proper mitochondrial function, was reduced by 52% in the old rats. A similar decrease occurred in ubiquinone, an important component of mitochondrial energy production. The older rats also had decreased concentrations of carnitine, a substance that transports fatty acids into the mitochondria for energy production.
We evaluated the antioxidant status of the liver and heart cells. Total cell glutathione level in the old rats was reduced by about 40% compared to the levels in younger rats. Mitochondrial glutathione was reduced by 79% in the old rats, possibly due to additional oxidative stress with age. The ascorbate (vitamin C) content of both the heart and liver cells from the old rats was reduced by half in the older rats. This may indicate an increased rate of ascorbate utilization or a decreased rate of uptake. Iron content was significantly increased in the brain cells from the old rats. These age-related changes in antioxidant status and iron content create a favorable environment for production of dangerous free radicals.
Acetylcarnitine is a naturally-occurring compound used to shuttle fatty acids to the mitochondria, where they are converted to energy. It may also increase neurotransmitter levels, such as acetylcholine.
To test whether acetylcarnitine supplementation improved mitochondrial function in old rats, we fed an acetylcarnitine-supplemented diet to young and old rats. Acetylcarnitine caused certain mitochondrial membrane properties in the old animals to improve to the level observed in young animals. Supplementation also increased or restored the cardiolipin content in liver cells obtained from old rats, but did not restore cell ascorbate content.
Lipoic acid is another naturally-occurring antioxidant compound that stimulates production of glutathione. It is considered to be a better antioxidant capabilities than even ascorbate.
To test the effect of lipoic acid on aging, we fed a lipoic acid-supplemented diet to young and old rats for two weeks. In the old animals, supplementation reversed the age-related decrease in ascorbate content in heart and liver cells. It also improved the ascorbate content in the cells from the young animals. Lipoic acid supplementation also reversed the accumulation of iron in the brain cells of the old animals.
In conclusion, we found that aging impaired mitochondrial and cellular function of liver, heart and brain cells. The results of our dietary studies indicate that supplementation with acetylcarnitine and lipoic acid may retard or reverse this impairment.
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